Addenbrooke’s Kidney Patients Association

High blood pressure is very common in people with kidney failure. Kidney failure causes high blood pressure and high blood pressure causes kidney failure. High blood pressure increases the likelihood of a stroke or a heart attack. It can be controlled by removing fluid from your body and by taking blood pressure tablets.

Many dialysis patients have anaemia, it makes them weak and tired. Anaemia is easy to treat with injections of erythropoietin (EPO). Patients on EPO treatment may need additional iron, either in the form of tablets or injections.

Renal bone disease is caused by low levels of calcium and vitamin D in the blood, and by high blood levels of phosphate. It is an important complication of kidney failure, without treatment it can cause bone pain and fractures. Although renal bone disease starts early in kidney failure, it does not usually cause problems until after dialysis has begun. A combination of dialysis and tablets usually reverses these problems but in some cases an operation (called parathyroidectomy) may be necessary.

Dialysis is the removal of body wastes and water from the blood. There are two types: haemodialysis (HD) and peritoneal dialysis (PD). In the UK, approximately half of the patients on dialysis have PD and the other half have HD – most patients can have either type. Both work in a similar way. Each method has two main processes:- Diffusion removes the body wastes and ultrafiltration removes the excess water.

What is the difference between the two dialysis systems?

PERITONEAL DIALYSIS

In Peritoneal dialysis the process takes place inside the patients abdomen, it is suitable for most people with End-Stage Renal Failure (ESRF). The abdominal lining acts as the dialysis membrane. Dialysis fluid from a bag is drained into the peritoneal cavity in the abdomen, left there until dialysis has taken place, and then drained out. Patients are trained to do this themselves at home which gives them independence, although storage space is needed to accommodate bulky supplies of dialysis fluid. Peritonitis is the main problem with PD.

HAEMODIALYSIS

In haemodialysis the process takes place inside a machine, it is suitable for most people with kidney failure. Blood is taken from the body, pumped into the dialysis machine, cleaned and pumped back into the body. It is usually done three times a week, each session lasting 3 to 5 hours. Access to the patient’s blood stream is usually by a dialysis catheter (plastic tube inserted into a large vein) or a fistula (made by joining a vein to an artery). Most patients have haemodialysis in a hospital, but some have it in a satellite dialysis unit or at home. Some patients may feel sick or dizzy during a session. Haemodialysis patients have a stricter fluid restriction than PD patients.

For the right patient at the right time, a transplant is the best treatment for End-Stage Renal Failure. If it works well the patient will be totally free from dialysis. Many patients with kidney failure are suitable for a transplant. Suitability is more important than age. Transplants are matched to the patient in terms of blood group and tissue type.

There are three sources of transplant kidneys:

• Cadaveric transplants
• Living related transplants
• Living unrelated transplants

The transplant waiting list works on the basis of finding the right kidney for the right person ie patients do not form a queue. The average waiting time in the UK is two years. Transplants do not last forever, transplants from living relatives last longest. If a transplant fails the patient can go back to dialysis or have another transplant. Patients have to take immuno-suppressant drugs daily to prevent their body rejecting a transplant. These drugs have side effects, including an increased risk of developing some types of cancer.

Good nutrition is important for all kidney patients at every stage of kidney disease from helping to prevent the progression of kidney disease, managing end stage kidney disease (on dialysis) through to maintaining a post-transplant healthy diet. Dietary advice differs according to the stage of kidney failure and the type of treatment given. Kidney patients should only alter their diet when advised to do so by their doctor or dietician. Malnutrition is the major problem for many patients on dialysis – both peritoneal dialysis (PD) and haemodialysis. So, high protein intakes are recommended. Potassium restriction is generally not needed on PD but may be needed on haemodialysis. Salt intake may need to be restricted. Most transplant patients will not have any dietary restrictions.

Signs and symptoms of chronic kidney disease develop over time if kidney damage progresses slowly. Loss of kidney function can cause a buildup of fluid or body waste or electrolyte problems. Depending on how severe it is, loss of kidney function can cause:

• Nausea
• Vomiting
• Loss of appetite
• Fatigue and weakness
• Sleep problems
• Urinating more or less
• Decreased mental sharpness
• Muscle cramps
• Swelling of feet and ankles
• Dry, itchy skin
• High blood pressure (hypertension) that’s difficult to control
• Shortness of breath, if fluid builds up in the lungs
• Chest pain, if fluid builds up around the lining of the heart

Signs and symptoms of kidney disease are often nonspecific. This means they can also be caused by other illnesses. Because your kidneys are able to make up for lost function, you might not develop signs and symptoms until irreversible damage has occurred.

Various coping strategies can help people deal with the psychological problems that often occur with kidney failure.